SLC38A1

Entrez Summary: N/A
UniProt Summary: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. {ECO:0000269|PubMed:10891391}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

amino acid:sodium symporter activity
neutral amino acid transmembrane transporter activity
L-amino acid transmembrane transporter activity
neurotransmitter uptake
neutral amino acid transport
amino acid transmembrane transporter activity
L-alpha-amino acid transmembrane transport
L-amino acid transport
amino acid transmembrane transport
amino acid transport
carboxylic acid transmembrane transport
organic acid transmembrane transport
sodium ion transport
neurotransmitter transport
anion transmembrane transport
organic acid transport
carboxylic acid transport
regulation of neurotransmitter levels
monovalent inorganic cation transport
organic anion transport
anion transport
metal ion transport
import into cell
cation transport
ion transmembrane transport
transmembrane transport
ion transport
integral component of plasma membrane
nitrogen compound transport