SNAPC4

Entrez Summary: This gene encodes the largest subunit of the small nuclear RNA-activating protein (SNAP) complex. The encoded protein contains a Myb DNA-binding domain, and is essential for RNA polymerase II and III polymerase transcription from small nuclear RNA promoters. A mutation in this gene is associated with ankylosing spondylitis. [provided by RefSeq, Jul 2016].
UniProt Summary: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CoCl2 18μM R07 exp346	-1.96
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.86
Artemisinin 50μM R08 exp450	-1.79
2-Deoxy-D-glucose 800μM R05 exp214	-1.73
UM131593 0.1μM R01 exp58	1.7
Lead acetate 2000μM R08 exp497	2.17
iCRT14 30μM R08 exp492	2.19
Vitamin-D3 40μM R08 exp536	2.48

Global Fraction of Cell Lines Where Essential: 136/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	7/28
bone	8/25
breast	5/33
central nervous system	11/56
cervix	1/4
colorectal	5/17
esophagus	2/13
fibroblast	0/1
gastric	2/15
kidney	3/21
liver	3/20
lung	10/75
lymphocyte	6/14
ovary	5/26
pancreas	2/24
peripheral nervous system	5/16
plasma cell	4/15
prostate	1/1
skin	5/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	2/5

Expression Distribution

snRNA-activating protein complex
snRNA transcription by RNA polymerase III
transcription by RNA polymerase III
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression