SOS2

Entrez Summary: This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9. [provided by RefSeq, Jul 2016].
UniProt Summary: Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000250|UniProtKB:Q62245}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nucleosome
Rho guanyl-nucleotide exchange factor activity
positive regulation of small GTPase mediated signal transduction
regulation of Rho protein signal transduction
regulation of Ras protein signal transduction
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
protein heterodimerization activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
positive regulation of intracellular signal transduction
G protein-coupled receptor signaling pathway
DNA binding
regulation of apoptotic process
regulation of programmed cell death
positive regulation of signal transduction
regulation of cell death
intracellular signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction