SRCAP

Entrez Summary: This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012].
UniProt Summary: Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.33
Palbociclib 1μM R07 exp382	-2.09
Vinblastine 0.2μM R03 exp108	-1.87
THZ531 0.225μM R08 exp444	-1.77
FBS-Wisent 0.1 R07 exp426	-1.77
All-trans-Retinoic-Acid 40μM R07 exp334	1.74
I-BRD9 4μM R07 exp365	2.08
Citral 75μM R06 exp275	2.1

Global Fraction of Cell Lines Where Essential: 115/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	9/28
bone	6/25
breast	3/33
central nervous system	15/56
cervix	1/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	2/15
kidney	3/21
liver	4/20
lung	10/75
lymphocyte	2/14
ovary	4/26
pancreas	3/24
peripheral nervous system	0/16
plasma cell	4/15
prostate	1/1
skin	4/24
soft tissue	2/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	5/29
uterus	0/5

Expression Distribution

Swr1 complex
helicase activity
histone exchange
histone acetyltransferase activity
ATP-dependent chromatin remodeling
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
histone binding
protein acetylation
gene silencing
nucleosome organization
chromatin remodeling
protein acylation
ATPase activity
protein-DNA complex subunit organization
nuclear body
transcription coactivator activity
peptidyl-lysine modification
histone modification
covalent chromatin modification
protein-containing complex
perinuclear region of cytoplasm
chromatin organization
viral process
symbiotic process
interspecies interaction between organisms
peptidyl-amino acid modification
Golgi apparatus
chromosome organization
DNA binding
ATP binding
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process
protein-containing complex subunit organization
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process