STAMBPL1

Entrez Summary: N/A
UniProt Summary: Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. {ECO:0000269|PubMed:18758443}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cidofovir 10μM R07 exp345	-1.94
Oligomycin-A 2μM R00 exp25	1.7
Sulforaphane 9μM R08 exp526 no dilution day6	1.74
Rifampicin 10μM R00 exp32	1.76
Pimelic-diphenylamide-106 5μM R00 exp28	2.05
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.24

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Lys63-specific deubiquitinase activity
protein K63-linked deubiquitination
metallopeptidase activity
thiol-dependent ubiquitin-specific protease activity
endosome
protein deubiquitination
protein modification by small protein removal
protein modification by small protein conjugation or removal
proteolysis
membrane