STK10

Entrez Summary: N/A
UniProt Summary: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotinate 1000μM R03 exp140	-2.43
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.94
BH1 1μM R04 exp169	-1.89
Nutlin-3A 1.6μM R06 exp294	-1.74
PFI-2 4μM R05 exp239	1.7
Wortmannin 0.5μM R00 exp37	1.86

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lymphocyte aggregation
leukocyte aggregation
leukocyte cell-cell adhesion
regulation of lymphocyte migration
specific granule membrane
stress-activated protein kinase signaling cascade
protein autophosphorylation
regulation of leukocyte migration
activation of protein kinase activity
protein serine/threonine kinase activity
signal transduction by protein phosphorylation
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
cell-cell adhesion
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
positive regulation of protein kinase activity
positive regulation of kinase activity
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
positive regulation of transferase activity
regulated exocytosis
leukocyte mediated immunity
exocytosis
regulation of protein kinase activity
regulation of cell migration
regulation of kinase activity
protein homodimerization activity
regulation of cell motility
leukocyte activation
cell adhesion
biological adhesion
protein phosphorylation
regulation of transferase activity
regulation of locomotion