SYS1

Entrez Summary: N/A
UniProt Summary: Involved in protein trafficking. May serve as a receptor for ARFRP1.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Monensin 0.3μM R08 exp507	-2.93
Rotenone 20μM R00 exp34	-2.57
Vemurafenib 6.6μM R08 exp434	-2.52
CB-5083 0.4μM R08 exp468	-2.45
Etoposide 1μM R00 exp19	-2.39
Vemurafenib 6.6μM R02 exp89	-2.39
Nicotine 3000μM R08 exp510	-2.3
A-196 10μM R03 exp114	-2.27
Pimelic-diphenylamide-106 5μM R00 exp28	-2.25
MLN-4924 2μM R00 exp22	-2.22
Ribavirin 10 to 15μM on day4 R04 exp160	-2
Cerivastatin 0.15μM R05 exp226	-1.96
SNS-032 25μM R07 exp401	-1.95
Nocodazole 0.1μM R03 exp94	-1.92
DABN 20μM R00 exp17	-1.91
Wortmannin 5μM R00 exp38	-1.9
Rifampicin 1μM R00 exp31	-1.85
MK2206 4μM R08 exp504	-1.74
GSK461364A 0.1μM R03 exp126	-1.71

Global Fraction of Cell Lines Where Essential: 669/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	23/28
bone	25/26
breast	25/33
central nervous system	55/56
cervix	4/4
colorectal	12/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	17/21
liver	19/20
lung	64/75
lymphocyte	16/16
ovary	21/26
pancreas	22/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	24/29
uterus	4/5

Expression Distribution

Golgi to endosome transport
protein localization to Golgi apparatus
Golgi to plasma membrane protein transport
establishment of protein localization to plasma membrane
Golgi to plasma membrane transport
integral component of Golgi membrane
trans-Golgi network membrane
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
cytosolic transport
trans-Golgi network
protein localization to plasma membrane
protein localization to cell periphery
establishment of protein localization to membrane
Golgi vesicle transport
protein localization to membrane
protein localization to organelle
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport