TCHP

Entrez Summary: N/A
UniProt Summary: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598). {ECO:0000269|PubMed:15731013, ECO:0000269|PubMed:18931701, ECO:0000269|PubMed:25270598}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Wiskostatin 3μM R07 exp422	-2.2
BI-D1870 3.15μM R02 exp66	-2.14
UM131593 0.1μM R01 exp58	-1.95
LLY-283 2.6μM R06 exp290	-1.94
MLN-4924 2μM R00 exp22	-1.93
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.86
FBS-Wisent 0.1 R07 exp426	-1.76
Curcumin 6.5μM R06 exp277	-1.74
ABT-702 5μM R06 exp261	-1.71
A-366 10μM R03 exp115	1.87
Cannabidiol 13μM R08 exp465	1.98
GSK591 2.6μM R03 exp128	1.99
MS094 2μM R03 exp136	1.99
Taxol 0.004μM R03 exp103	2.06
Celastrol 0.12μM R05 exp225	2.11
Hypoxia 5%O2 R04 exp191	2.14

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

apical cortex
negative regulation of cilium assembly
negative regulation of plasma membrane bounded cell projection assembly
desmosome
negative regulation of organelle assembly
regulation of cilium assembly
keratin filament
negative regulation of cell projection organization
negative regulation of cell growth
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of organelle assembly
negative regulation of growth
negative regulation of organelle organization
regulation of cell growth
centrosome
regulation of growth
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
apoptotic process
regulation of cellular component biogenesis
programmed cell death
cell death
cell projection organization
mitochondrion
regulation of organelle organization