TEX10

Entrez Summary: N/A
UniProt Summary: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). {ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 84/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	6/28
bone	2/25
breast	4/33
central nervous system	4/56
cervix	0/4
colorectal	5/17
esophagus	3/13
fibroblast	0/1
gastric	2/15
kidney	3/21
liver	2/20
lung	12/75
lymphocyte	0/14
ovary	4/26
pancreas	4/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	1/7
thyroid	1/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	2/5

Expression Distribution

Rix1 complex
MLL1 complex
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA metabolic process
gene expression