TGIF2

Gene Information

Official Symbol: TGIF2
Official Name: TGFB induced factor homeobox 2
Aliases and Previous Symbols: N/A
Entrez ID: 60436
UniProt: Q9GZN2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. {ECO:0000269|PubMed:11427533}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-1.77
LLY-284 2.6μM R06 exp291	-1.73
Trimetrexate 0.03μM R08 exp535	-1.72
HMS-I1 1μM R01 exp46	1.82
Erlotinib 10μM R05 exp216	1.87
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.93
GSK461364A 0.1μM R03 exp126	2.08
Vemurafenib 6.6μM R08 exp434	2.13

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7070
Expression level (log2 read counts): 5.51

Expression Distribution

Homeobox KN
Homeobox

nodal signaling pathway
activin receptor signaling pathway
regulation of gastrulation
regulation of embryonic development
retina development in camera-type eye
transmembrane receptor protein serine/threonine kinase signaling pathway
camera-type eye development
eye development
visual system development
positive regulation of neuron differentiation
sensory system development
positive regulation of neurogenesis
positive regulation of nervous system development
positive regulation of cell development
sensory organ development
regulation of neuron differentiation
DNA-binding transcription factor activity
enzyme linked receptor protein signaling pathway
regulation of neurogenesis
negative regulation of transcription by RNA polymerase II
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
regulation of anatomical structure morphogenesis
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
positive regulation of developmental process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
generation of neurons
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis
negative regulation of gene expression
positive regulation of multicellular organismal process