TGM2
Gene Information
- Official Symbol: TGM2
- Official Name: transglutaminase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 7052
- UniProt: P21980
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Pfam Domains GO Terms
Pfam Domains
| Transglut C |
| Transglut core |
| Transglut N |
GO Terms
| isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine |
| isopeptide cross-linking |
| peptidyl-glutamine modification |
| tube lumen cavitation |
| salivary gland cavitation |
| negative regulation of endoplasmic reticulum calcium ion concentration |
| protein-glutamine gamma-glutamyltransferase activity |
| positive regulation of mitochondrial calcium ion concentration |
| branching involved in salivary gland morphogenesis |
| endoplasmic reticulum calcium ion homeostasis |
| mitochondrial calcium ion homeostasis |
| salivary gland morphogenesis |
| positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
| salivary gland development |
| blood vessel remodeling |
| intrinsic component of plasma membrane |
| apoptotic cell clearance |
| exocrine system development |
| peptide cross-linking |
| positive regulation of smooth muscle cell proliferation |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| gland morphogenesis |
| tissue remodeling |
| regulation of smooth muscle cell proliferation |
| positive regulation of inflammatory response |
| tube formation |
| morphogenesis of a branching epithelium |
| morphogenesis of a branching structure |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| protein domain specific binding |
| positive regulation of cytosolic calcium ion concentration |
| peptidyl-lysine modification |
| regulation of cytosolic calcium ion concentration |
| phagocytosis |
| regulation of inflammatory response |
| protein homooligomerization |
| collagen-containing extracellular matrix |
| GTP binding |
| positive regulation of cell adhesion |
| gland development |
| focal adhesion |
| morphogenesis of an epithelium |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| positive regulation of defense response |
| divalent inorganic cation homeostasis |
| protein complex oligomerization |
| cellular metal ion homeostasis |
| tissue morphogenesis |
| positive regulation of response to external stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| tube morphogenesis |
| regulation of cell adhesion |
| positive regulation of cell death |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of defense response |
| ion homeostasis |
| tube development |
| peptidyl-amino acid modification |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| positive regulation of cell population proliferation |
| animal organ morphogenesis |
| endoplasmic reticulum |
| positive regulation of intracellular signal transduction |
| regulation of response to external stimulus |
| chemical homeostasis |
| epithelium development |
| mitochondrion |
| G protein-coupled receptor signaling pathway |
| regulation of response to stress |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| tissue development |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15731
- Expression level (log2 read counts): 2.61
Expression Distribution
TGM2 Expression in NALM6 Cells: 2.61
