THOC1

Gene Information

Official Symbol: THOC1
Official Name: THO complex 1
Aliases and Previous Symbols: N/A
Entrez ID: 9984
UniProt: Q96FV9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BAY-598 4μM R05 exp220	1.7
Chloramphenicol 2μM R00 exp12	1.74
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.76
TGF-beta1 44ng/ml R08 exp528	2.06

Global Fraction of Cell Lines Where Essential: 517/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	20/28
blood	21/28
bone	18/26
breast	21/33
central nervous system	40/56
cervix	2/4
colorectal	15/17
esophagus	5/13
fibroblast	0/1
gastric	13/16
kidney	13/21
liver	18/20
lung	51/75
lymphocyte	11/16
ovary	20/26
pancreas	16/24
peripheral nervous system	8/16
plasma cell	12/15
prostate	0/1
skin	20/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	11/22
urinary tract	17/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 836
Expression level (log2 read counts): 6.76

Expression Distribution

Gene	Correlation
TFIP11	0.435
NUP43	0.433
UBAP1	0.421
FOXD4L2	0.412
SUPT5H	0.412
PSMD3	0.41
OR10G3	0.41
RPSA	0.405

Death
efThoc1

negative regulation of isotype switching to IgA isotypes
negative regulation of isotype switching
negative regulation of DNA damage checkpoint
THO complex
negative regulation of cell cycle checkpoint
regulation of isotype switching to IgA isotypes
THO complex part of transcription export complex
viral mRNA export from host cell nucleus
translocation of molecules into other organism involved in symbiotic interaction
translocation of molecules into host
negative regulation of B cell mediated immunity
negative regulation of immunoglobulin mediated immune response
negative regulation of immunoglobulin production
transcription export complex
regulation of DNA damage checkpoint
negative regulation of B cell activation
positive regulation of DNA-templated transcription, elongation
regulation of cell cycle checkpoint
replication fork processing
regulation of isotype switching
negative regulation of production of molecular mediator of immune response
negative regulation of lymphocyte mediated immunity
DNA-dependent DNA replication maintenance of fidelity
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
negative regulation of adaptive immune response
negative regulation of DNA recombination
negative regulation of leukocyte mediated immunity
regulation of DNA-templated transcription, elongation
regulation of immunoglobulin mediated immune response
regulation of B cell mediated immunity
intercellular bridge
regulation of immunoglobulin production
multi-organism transport
multi-organism localization
negative regulation of response to DNA damage stimulus
mRNA 3-end processing
regulation of DNA recombination
mRNA export from nucleus
mRNA-containing ribonucleoprotein complex export from nucleus
nuclear matrix