TMX1

Entrez Summary: N/A
UniProt Summary: May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotinamide Riboside 100μM R03 exp139	-2.02
JQ1 0.01μM R03 exp130	-1.99
Momordin-Ic 10μM R08 exp506	-1.76
SGC0649 7μM R03 exp150	-1.7
Hippuristanol 0.12μM R08 exp488	1.91
UM0011500 10μM R05 exp246	1.97
Staurosporine 0.02μM R08 exp524	2.13

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

disulfide oxidoreductase activity
cell redox homeostasis
response to endoplasmic reticulum stress
cellular homeostasis
endoplasmic reticulum membrane
oxidation-reduction process
homeostatic process
cellular response to stress