TNP1

Entrez Summary: N/A
UniProt Summary: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. {ECO:0000250|UniProtKB:P10856}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-1.91
NMS-873 0.07μM R07 exp380	-1.74
Actinomycin-D 0.01μM R00 exp4	-1.71
Apcin 50 to 100μM on day4 R04 exp176	-1.71
Oligomycin-A 20μM R00 exp26	1.73
Arsenate 40μM R06 exp264	1.76
Nifurtimox 1μM R03 exp141	1.82
MLN-4924 2μM R00 exp22	1.83
Wortmannin 5μM R00 exp38	1.85
Pimelic-diphenylamide-106 5μM R00 exp28	1.88
Taxol 0.002μM R01 exp54	1.95
Vinblastine 0.002μM R01 exp60	2.08
Thimerosal 0.85μM R08 exp529	2.5

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

fertilization, exchange of chromosomal proteins
sperm chromatin decondensation
male pronucleus assembly
spermatid nucleus elongation
single strand break repair
spermatogenesis, exchange of chromosomal proteins
sperm chromatin condensation
nuclear nucleosome
male germ cell nucleus
nucleosome disassembly
chromatin disassembly
protein-DNA complex disassembly
spermatid nucleus differentiation
positive regulation of protein processing
positive regulation of protein maturation
histone exchange
chromatin organization involved in negative regulation of transcription
chromatin silencing
regulation of protein processing
nucleosome
regulation of protein maturation
chromatin organization involved in regulation of transcription
flagellated sperm motility
sperm motility
ATP-dependent chromatin remodeling
negative regulation of gene expression, epigenetic
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
nucleus organization
single fertilization
spermatid development
gene silencing
chromatin assembly or disassembly
spermatid differentiation
nucleosome organization
chromatin remodeling
fertilization
DNA packaging
regulation of gene expression, epigenetic
protein-containing complex disassembly