TRAPPC3

Entrez Summary: This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
UniProt Summary: May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	-2.27
Phenformin 20μM R03 exp143	-2.06
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.05
Cerivastatin 0.15μM R05 exp226	-1.92
Tozasertib 0.1μM R07 exp414	-1.91
5-Fluorouracil 2μM R00 exp1	-1.9
Apcin 25μM plus proTAME 2μM R04 exp177	-1.89
All-trans-Retinoic-Acid 40μM R07 exp334	-1.88
Cycloheximide 0.2μM R00 exp15	-1.87
Resminostat 0.5μM R07 exp393	-1.85
Metformin 100 to 150μM on day4 R04 exp170	-1.81
DABN 2μM R00 exp16	-1.76
UM0131023 0.05μM R05 exp248	-1.75
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.74
TRAIL 50ng/ml R00 exp36	-1.7
SNS-032 25μM R07 exp401	1.96

Global Fraction of Cell Lines Where Essential: 721/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	25/26
breast	31/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	15/16
kidney	20/21
liver	20/20
lung	74/75
lymphocyte	15/16
ovary	26/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	29/29
uterus	5/5

Expression Distribution

cis-Golgi network membrane
TRAPP complex
intra-Golgi vesicle-mediated transport
Rab guanyl-nucleotide exchange factor activity
COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
vesicle targeting
vesicle budding from membrane
establishment of vesicle localization
vesicle localization
endoplasmic reticulum to Golgi vesicle-mediated transport
vesicle organization
establishment of organelle localization
Golgi vesicle transport
organelle localization
Golgi membrane
membrane organization
Golgi apparatus
endoplasmic reticulum
intracellular transport
protein-containing complex assembly
establishment of localization in cell
protein-containing complex subunit organization
vesicle-mediated transport