TRIM26

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA- encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. {ECO:0000269|PubMed:25763818, ECO:0000269|PubMed:26611359}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of viral release from host cell
negative regulation of viral entry into host cell
regulation of viral entry into host cell
regulation of viral release from host cell
transferase activity
interferon-gamma-mediated signaling pathway
negative regulation of viral life cycle
negative regulation of viral process
regulation of viral life cycle
cellular response to interferon-gamma
response to interferon-gamma
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
positive regulation of DNA-binding transcription factor activity
negative regulation of locomotion
regulation of DNA-binding transcription factor activity
cellular component
cytokine-mediated signaling pathway
innate immune response
regulation of multi-organism process
zinc ion binding
defense response to other organism
regulation of locomotion
cellular response to cytokine stimulus
response to cytokine
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
DNA binding
positive regulation of molecular function
immune response