TRMT112

Gene Information
  • Official Symbol: TRMT112
  • Official Name: tRNA methyltransferase subunit 11-2
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 51504
  • UniProt: Q9UI30
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L- methionine as methyl donor (PubMed:18539146). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604). {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:25851604}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 252
  • Expression level (log2 read counts): 6.2

Expression Distribution

  • Last modified: 2026/01/07 22:37
  • by 127.0.0.1