TTC7A

Entrez Summary: This gene encodes a protein containing tetratricopeptide repeats. Mutations in this gene disrupt intestinal development and can cause early onset inflammatory bowel disease and intestinal atresia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
UniProt Summary: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lead acetate 2000μM R08 exp498 no dilution day6	-2.44
Vincristine 0.0005μM R04 exp190	-2.22
DABN racemic mixture R03 exp93	-2.02
MLN-4924 0.2μM R00 exp21	-1.95
LY2090314 0.003μM R08 exp499	-1.86
Colchicine 0.009μM R05 exp215	-1.77
SB743921 0.001μM R05 exp244	-1.76
Sulforaphane 9μM R08 exp525	-1.76
Vinblastine 0.002μM R01 exp60	-1.75
Thapsigargin 0.005μM R07 exp407	-1.71
Chloroquine 32μM R08 exp470	1.74
Pyronaridine 1μM R06 exp295	1.78
VER-155008 3.9μM R06 exp301	1.8
FBS-Wisent 0.1 R07 exp426	1.83
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.4

Global Fraction of Cell Lines Where Essential: 11/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	3/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylinositol phosphorylation
cellular iron ion homeostasis
lipid phosphorylation
iron ion homeostasis
cellular transition metal ion homeostasis
transition metal ion homeostasis
phosphatidylinositol metabolic process
protein localization to plasma membrane
lipid modification
protein localization to cell periphery
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
protein localization to membrane
cellular metal ion homeostasis
hemopoiesis
hematopoietic or lymphoid organ development
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
immune system development
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
organophosphate metabolic process
cellular homeostasis
cellular lipid metabolic process
chemical homeostasis
lipid metabolic process
phosphorylation
cellular protein localization
cellular macromolecule localization
homeostatic process