TXNL1

Entrez Summary: N/A
UniProt Summary: Active thioredoxin with a redox potential of about -250 mV. {ECO:0000269|PubMed:19349277}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 2μM R05 exp210	-2.16
Tubastatin-A 2.5μM R07 exp417	-2.13
BI-2536 0.001μM R01 exp41	1.72
Nifuroxazide 1μM R01 exp51	1.74
CB-5083 0.4μM R08 exp468	1.75
Lapatinib 5μM R01 exp47	1.81
Vinblastine 0.2μM R03 exp108	1.81
RS-1 10μM R08 exp519	1.87
Nocodazole 0.1μM R03 exp94	1.92
Nicotinamide Riboside 100μM R03 exp139	2.04

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PITH
Thioredoxin

disulfide oxidoreductase activity
proteasome complex
cell redox homeostasis
cellular homeostasis
oxidation-reduction process
homeostatic process