UBA52
Gene Information
- Official Symbol: UBA52
- Official Name: ubiquitin A-52 residue ribosomal protein fusion product 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7311
- UniProt: P62987
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L40e |
| ubiquitin |
| Rad60-SLD |
GO Terms
| protein tag |
| response to insecticide |
| error-free translesion synthesis |
| error-prone translesion synthesis |
| nucleotide-excision repair, DNA duplex unwinding |
| nucleotide-excision repair, DNA damage recognition |
| nucleotide-excision repair, DNA gap filling |
| global genome nucleotide-excision repair |
| nucleotide-binding oligomerization domain containing signaling pathway |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
| nucleotide-excision repair, preincision complex assembly |
| TRIF-dependent toll-like receptor signaling pathway |
| MyD88-independent toll-like receptor signaling pathway |
| MyD88-dependent toll-like receptor signaling pathway |
| cytoplasmic pattern recognition receptor signaling pathway |
| nucleotide-excision repair, DNA incision, 5-to lesion |
| virion assembly |
| DNA damage response, detection of DNA damage |
| nucleotide-excision repair, DNA incision |
| translesion synthesis |
| cytosolic small ribosomal subunit |
| DNA synthesis involved in DNA repair |
| interstrand cross-link repair |
| postreplication repair |
| intracellular transport of virus |
| host cell |
| transport of virus |
| cytosolic large ribosomal subunit |
| protein targeting to peroxisome |
| endocytic vesicle membrane |
| protein localization to peroxisome |
| establishment of protein localization to peroxisome |
| I-kappaB kinase/NF-kappaB signaling |
| multi-organism transport |
| peroxisomal transport |
| multi-organism localization |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| transcription-coupled nucleotide-excision repair |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| peroxisome organization |
| anaphase-promoting complex-dependent catabolic process |
| JNK cascade |
| interleukin-1-mediated signaling pathway |
| SRP-dependent cotranslational protein targeting to membrane |
| toll-like receptor signaling pathway |
| cotranslational protein targeting to membrane |
| transforming growth factor beta receptor signaling pathway |
| stress-activated MAPK cascade |
| DNA biosynthetic process |
| protein targeting to ER |
| nucleotide-excision repair |
| DNA duplex unwinding |
| regulation of transforming growth factor beta receptor signaling pathway |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| regulation of cellular response to transforming growth factor beta stimulus |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| DNA geometric change |
| regulation of DNA-templated transcription in response to stress |
| pattern recognition receptor signaling pathway |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| stress-activated protein kinase signaling cascade |
| vesicle |
| translational initiation |
| negative regulation of cellular response to growth factor stimulus |
| positive regulation of NF-kappaB transcription factor activity |
| activation of MAPK activity |
| cellular response to transforming growth factor beta stimulus |
| protein targeting to membrane |
| response to transforming growth factor beta |
| mitochondrial outer membrane |
| intracellular receptor signaling pathway |
| structural constituent of ribosome |
| cellular response to interleukin-1 |
| regulation of mRNA stability |
| regulation of RNA stability |
| cellular response to hypoxia |
| nuclear-transcribed mRNA catabolic process |
| cellular response to decreased oxygen levels |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| response to interleukin-1 |
| protein-DNA complex assembly |
| viral life cycle |
| regulation of mRNA catabolic process |
| endosome membrane |
| cellular response to oxygen levels |
| mRNA catabolic process |
| endosomal transport |
| innate immune response-activating signal transduction |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| protein-DNA complex subunit organization |
| RNA catabolic process |
| activation of innate immune response |
| positive regulation of MAP kinase activity |
| positive regulation of DNA-binding transcription factor activity |
| establishment of protein localization to membrane |
| regulation of cellular response to growth factor stimulus |
| protein deubiquitination |
| ubiquitin protein ligase binding |
| protein modification by small protein removal |
| DNA conformation change |
| nucleic acid phosphodiester bond hydrolysis |
| protein polyubiquitination |
| lysosomal membrane |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| activation of protein kinase activity |
| regulation of mRNA metabolic process |
| positive regulation of protein serine/threonine kinase activity |
| positive regulation of innate immune response |
| regulation of MAP kinase activity |
| response to hypoxia |
| proteasomal protein catabolic process |
| cell-cell signaling by wnt |
| response to decreased oxygen levels |
| protein targeting |
| Wnt signaling pathway |
| positive regulation of response to biotic stimulus |
| MAPK cascade |
| nucleobase-containing compound catabolic process |
| response to oxygen levels |
| translation |
| signal transduction by protein phosphorylation |
| peptide biosynthetic process |
| regulation of DNA-binding transcription factor activity |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| regulation of innate immune response |
| positive regulation of defense response |
| protein localization to membrane |
| organic cyclic compound catabolic process |
| cellular response to growth factor stimulus |
| response to toxic substance |
| DNA repair |
| positive regulation of multi-organism process |
| regulation of protein serine/threonine kinase activity |
| regulation of response to biotic stimulus |
| posttranscriptional regulation of gene expression |
| ubiquitin-dependent protein catabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| response to growth factor |
| modification-dependent protein catabolic process |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| modification-dependent macromolecule catabolic process |
| immune response-activating signal transduction |
| positive regulation of kinase activity |
| proteolysis involved in cellular protein catabolic process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| cellular protein catabolic process |
| activation of immune response |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| protein catabolic process |
| protein ubiquitination |
| detection of stimulus |
| mRNA metabolic process |
| positive regulation of cell death |
| viral process |
| enzyme linked receptor protein signaling pathway |
| protein localization to organelle |
| DNA metabolic process |
| regulation of MAPK cascade |
| regulation of defense response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| symbiotic process |
| cellular amide metabolic process |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| regulation of cellular catabolic process |
| cellular protein-containing complex assembly |
| membrane organization |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| cellular macromolecule catabolic process |
| endoplasmic reticulum membrane |
| protein phosphorylation |
| regulation of transferase activity |
| protein modification by small protein conjugation or removal |
| negative regulation of cell death |
| regulation of catabolic process |
| intracellular protein transport |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| macromolecule catabolic process |
| positive regulation of phosphorylation |
| organonitrogen compound catabolic process |
| chromosome organization |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| cell-cell signaling |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| proteolysis |
| transmembrane transport |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| negative regulation of cellular biosynthetic process |
| intracellular transport |
| peptide transport |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| extracellular space |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| RNA metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 11/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 2/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 600
- Expression level (log2 read counts): 7.89
Expression Distribution
UBA52 Expression in NALM6 Cells: 7.89
