UBD

Gene Information

Official Symbol: UBD
Official Name: ubiquitin D
Aliases and Previous Symbols: N/A
Entrez ID: 10537
UniProt: O15205
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)- associated nephropathy (HIVAN). {ECO:0000269|PubMed:15831455, ECO:0000269|PubMed:16495226, ECO:0000269|PubMed:16495380, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:18574467, ECO:0000269|PubMed:19028597, ECO:0000269|PubMed:19033385, ECO:0000269|PubMed:19166848, ECO:0000269|PubMed:19726511, ECO:0000269|PubMed:19959714}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18801
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
CCT251545 20μM R07 exp326	-1.78
Beta-Estradiol 0.55μM R07 exp425	-1.75
Losmapimod 1μM R07 exp376	-1.74

aggresome assembly
inclusion body assembly
proteasome binding
myeloid dendritic cell differentiation
myeloid dendritic cell activation
dendritic cell differentiation
aggresome
myeloid leukocyte differentiation
fibrillar center
response to interferon-gamma
positive regulation of I-kappaB kinase/NF-kappaB signaling
myeloid cell differentiation
regulation of I-kappaB kinase/NF-kappaB signaling
response to tumor necrosis factor
leukocyte differentiation
post-translational protein modification
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
hemopoiesis
myeloid leukocyte activation
proteolysis involved in cellular protein catabolic process
hematopoietic or lymphoid organ development
cellular protein catabolic process
regulation of mitotic cell cycle
positive regulation of apoptotic process
immune system development
positive regulation of programmed cell death
protein catabolic process
protein ubiquitination
positive regulation of cell death
regulation of cell cycle process
innate immune response
protein modification by small protein conjugation
cellular macromolecule catabolic process
leukocyte activation
defense response to other organism
protein modification by small protein conjugation or removal