UBE2D2

Gene Information

Official Symbol: UBE2D2
Official Name: ubiquitin conjugating enzyme E2 D2
Aliases and Previous Symbols: N/A
Entrez ID: 7322
UniProt: P62837
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:15280377, ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:18703417, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20403326, ECO:0000269|PubMed:20525694}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ML-792 0.2μM R08 exp505	-2.55
Aphidicolin 0.4μM R08 exp440	-2.41
Tanespimycin 14μM R08 exp527	-2.16
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.85
Ethambutol 25μM R08 exp481	1.72
Rapamycin 1μM R00 exp29	1.94

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17204
Expression level (log2 read counts): 6.43

Expression Distribution

Gene	Correlation
OTUB1	0.473
UBE2D3	0.424

TRIF-dependent toll-like receptor signaling pathway
protein K11-linked ubiquitination
MyD88-independent toll-like receptor signaling pathway
ubiquitin conjugating enzyme activity
protein K48-linked ubiquitination
protein autoubiquitination
protein localization to peroxisome
protein targeting to peroxisome
establishment of protein localization to peroxisome
peroxisomal transport
peroxisome organization
toll-like receptor signaling pathway
ubiquitin ligase complex
pattern recognition receptor signaling pathway
innate immune response-activating signal transduction
ubiquitin-protein transferase activity
activation of innate immune response
ubiquitin protein ligase binding
protein polyubiquitination
positive regulation of innate immune response
protein targeting
positive regulation of response to biotic stimulus
establishment of protein localization to organelle
regulation of innate immune response
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
immune response-activating signal transduction
proteolysis involved in cellular protein catabolic process
protein-containing complex
immune response-regulating signaling pathway
positive regulation of response to external stimulus
cellular protein catabolic process
activation of immune response
protein catabolic process
protein ubiquitination
protein localization to organelle