UBE2S

Gene Information

Official Symbol: UBE2S
Official Name: ubiquitin conjugating enzyme E2 S
Aliases and Previous Symbols: N/A
Entrez ID: 27338
UniProt: Q16763
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle- regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874). {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22496338, ECO:0000269|PubMed:27259151}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Apcin 50 to 100μM on day4 R04 exp176	-4.33
proTAME 5μM R04 exp187	-3.39
Apcin 25μM plus proTAME 2μM R04 exp177	-3.24
BI-2536 0.0042μM R03 exp95	-1.99
Etoposide 0.1μM R05 exp198	-1.89
TRAIL 50ng/ml R00 exp36	-1.79
Centrinone 0.5μM R07 exp343	-1.78
Latrunculin-B 10μM R07 exp374	-1.78

Global Fraction of Cell Lines Where Essential: 20/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	4/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	3/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	0/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 7886
Expression level (log2 read counts): 7.77

Expression Distribution

Gene	Correlation
UBE2C	0.566
ANAPC13	0.5
KIF20A	0.465
MAD2L1BP	0.418
SKA1	0.418
ANAPC15	0.415

free ubiquitin chain polymerization
protein K27-linked ubiquitination
protein K29-linked ubiquitination
ubiquitin recycling
protein K6-linked ubiquitination
anaphase-promoting complex binding
positive regulation of ubiquitin protein ligase activity
exit from mitosis
anaphase-promoting complex
regulation of ubiquitin protein ligase activity
protein K11-linked ubiquitination
positive regulation of ubiquitin-protein transferase activity
protein K63-linked ubiquitination
ubiquitin conjugating enzyme activity
regulation of ubiquitin-protein transferase activity
anaphase-promoting complex-dependent catabolic process
protein polymerization
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
mitotic nuclear division
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
ubiquitin-protein transferase activity
mitotic cell cycle phase transition
cell cycle phase transition
nuclear division
protein polyubiquitination
organelle fission
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
cell division
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
mitotic cell cycle process
cellular protein catabolic process
positive regulation of transferase activity
mitotic cell cycle
protein catabolic process