USP25

Gene Information

Official Symbol: USP25
Official Name: ubiquitin specific peptidase 25
Aliases and Previous Symbols: N/A
Entrez ID: 29761
UniProt: Q9UHP3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hypoxia 5%O2 R04 exp191	-1.82
Nifuroxazide 5μM R03 exp102	-1.7
Hydroxyurea 100μM R07 exp329	1.74
Tanespimycin 14μM R08 exp527	1.78
Aphidicolin 0.4μM R08 exp440	1.79
3-Bromopyruvate 7μM R04 exp175	1.82
LLY-283 2.6μM R06 exp290	1.84
Clomiphene 4.4μM R02 exp68	2.03

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12141
Expression level (log2 read counts): 5.84

Expression Distribution

ubiquitin-like protein-specific protease activity
negative regulation of ERAD pathway
regulation of ERAD pathway
protein K63-linked deubiquitination
protein K48-linked deubiquitination
negative regulation of response to endoplasmic reticulum stress
thiol-dependent ubiquitinyl hydrolase activity
negative regulation of proteasomal protein catabolic process
negative regulation of proteolysis involved in cellular protein catabolic process
ATPase binding
ubiquitin binding
peptidase activity
regulation of response to endoplasmic reticulum stress
negative regulation of cellular protein catabolic process
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
negative regulation of protein catabolic process
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
protein deubiquitination
regulation of protein stability
ubiquitin protein ligase binding
protein modification by small protein removal
negative regulation of catabolic process
negative regulation of proteolysis
regulation of protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
regulation of proteolysis
regulation of cellular response to stress
regulation of cellular catabolic process
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
regulation of catabolic process