WAC

Gene Information

Official Symbol: WAC
Official Name: WW domain containing adaptor with coiled-coil
Aliases and Previous Symbols: N/A
Entrez ID: 51322
UniProt: Q9BTA9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ZLN024 50μM R08 exp538	-2.02
Bleomycin 5μM R08 exp459	-1.81
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.77
SB203580 25μM R03 exp149	1.74
Hydroxyurea 100μM R07 exp329	1.79
Pomalidomide 20μM R07 exp391	2.05

Global Fraction of Cell Lines Where Essential: 13/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	2/21
liver	0/20
lung	2/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2658
Expression level (log2 read counts): 7.46

Expression Distribution

histone H2B conserved C-terminal lysine ubiquitination
histone H2B ubiquitination
histone monoubiquitination
RNA polymerase II complex binding
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
histone ubiquitination
negative regulation of ubiquitin-dependent protein catabolic process
negative regulation of proteasomal protein catabolic process
protein monoubiquitination
G1 DNA damage checkpoint
positive regulation of macroautophagy
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of cellular protein catabolic process
spliceosomal complex
positive regulation of autophagy
regulation of proteasomal ubiquitin-dependent protein catabolic process
DNA damage checkpoint
negative regulation of protein catabolic process
DNA integrity checkpoint
regulation of ubiquitin-dependent protein catabolic process
regulation of macroautophagy
regulation of proteasomal protein catabolic process
cell cycle checkpoint
regulation of proteolysis involved in cellular protein catabolic process
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
negative regulation of catabolic process
regulation of autophagy
negative regulation of proteolysis
histone modification
positive regulation of cellular catabolic process
covalent chromatin modification
regulation of protein catabolic process
chromatin binding
nuclear speck
positive regulation of catabolic process
negative regulation of cell cycle
protein ubiquitination
chromatin organization
regulation of proteolysis