WDR48

Entrez Summary: The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is ubiquitinated in response to DNA damage. [provided by RefSeq, Sep 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
VER-155008 3.9μM R06 exp301	-2.07
BS-181 20μM R08 exp461	-2.01
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.78
3-Bromopyruvate 7μM R04 exp175	1.89
ML-792 0.2μM R08 exp505	1.89
Bortezomib 0.005μM R00 exp6	1.93
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.03
Actinomycin-D 0.001μM R00 exp3	2.1
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.15
Hippuristanol 0.12μM R08 exp488	2.17
Oligomycin-A 20μM R00 exp26	2.18
Amiloride 100μM R08 exp447	2.21

Global Fraction of Cell Lines Where Essential: 48/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	1/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	2/17
esophagus	2/13
fibroblast	0/1
gastric	0/16
kidney	7/21
liver	1/20
lung	10/75
lymphocyte	0/16
ovary	4/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	4/29
uterus	0/5

Expression Distribution

Gene	Correlation
WDR20	0.571
USP46	0.464

WD40
DUF3337

regulation of protein monoubiquitination
positive regulation of protein deubiquitination
regulation of protein deubiquitination
seminiferous tubule development
DNA damage response, detection of DNA damage
interstrand cross-link repair
ubiquitin binding
multicellular organism growth
double-strand break repair via homologous recombination
recombinational repair
late endosome
male gonad development
positive regulation of protein modification by small protein conjugation or removal
development of primary male sexual characteristics
single fertilization
male sex differentiation
fertilization
double-strand break repair
positive regulation of epithelial cell proliferation
regulation of protein ubiquitination
homeostasis of number of cells
gonad development
development of primary sexual characteristics
DNA recombination
regulation of protein modification by small protein conjugation or removal
skeletal system morphogenesis
lysosome
sex differentiation
protein deubiquitination
protein modification by small protein removal
regulation of epithelial cell proliferation
positive regulation of proteolysis
skin development
developmental growth
growth
reproductive structure development
reproductive system development
embryonic organ development
skeletal system development
DNA repair