XDH

Gene Information

Official Symbol: XDH
Official Name: xanthine dehydrogenase
Aliases and Previous Symbols: N/A
Entrez ID: 7498
UniProt: P47989
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014].
UniProt Summary: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). {ECO:0000269|PubMed:17301077}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PT-1 25μM R07 exp392	-1.92
AICAR 240μM R05 exp211	-1.9
MK2206 4μM R08 exp504	-1.8
PF-06409577 20μM R07 exp389	1.71
Cyclosporin-A 0.8μM R07 exp347	1.72
Deguelin 0.05μM R02 exp69	1.72
BI-2536 0.02μM R03 exp96	2.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8419
Expression level (log2 read counts): 1.21

Expression Distribution

Fer2
Fer2 2
FAD binding 5
Ald Xan dh C
CO deh flav C
Ald Xan dh C2

xanthine oxidase activity
negative regulation of vasculogenesis
xanthine catabolic process
xanthine dehydrogenase activity
xanthine metabolic process
purine nucleobase catabolic process
molybdopterin cofactor binding
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of endothelial cell differentiation
negative regulation of cellular response to vascular endothelial growth factor stimulus
nucleobase catabolic process
regulation of vasculogenesis
regulation of vascular endothelial growth factor signaling pathway
regulation of cellular response to vascular endothelial growth factor stimulus
purine nucleobase metabolic process
2 iron, 2 sulfur cluster binding
positive regulation of p38MAPK cascade
FAD binding
regulation of endothelial cell differentiation
negative regulation of endothelial cell proliferation
regulation of p38MAPK cascade
negative regulation of epithelial cell differentiation
nucleobase metabolic process
sarcoplasmic reticulum
purine nucleotide catabolic process
lactation
negative regulation of protein kinase B signaling
purine-containing compound catabolic process
flavin adenine dinucleotide binding
nucleotide catabolic process
nucleoside phosphate catabolic process
body fluid secretion
electron transfer activity
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of reactive oxygen species metabolic process
negative regulation of blood vessel morphogenesis
nucleobase-containing small molecule biosynthetic process
peroxisome
negative regulation of vasculature development
negative regulation of epithelial cell proliferation