YLPM1

Gene Information

Official Symbol: YLPM1
Official Name: YLP motif containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 56252
UniProt: P49750
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LLY-283 2.6μM R06 exp290	-2.84
Momordin-Ic 10μM R08 exp506	-2.77
BI-6727 0.0125μM R03 exp97	-2.72
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.34
Nocodazole 0.2μM R02 exp64	-2.31
Nicotinate 1000μM R03 exp140	-2.16
UM131593 0.2μM R03 exp106	-1.97
Docosahexaenoic-acid 50μM R07 exp356	-1.95
Sucrose 20000μM R06 exp298	-1.87
Trientine 500μM R08 exp534	-1.82
Pyridostatin 4μM R05 exp240	-1.71
Ribavirin 10 to 15μM on day4 R04 exp160	1.72
All-trans-Retinoic-Acid 8μM R07 exp333	1.78
Benzoate 20000μM R08 exp456	1.84
Erlotinib 10μM R05 exp216	1.86
LJH685 50μM R08 exp433	1.87
Sulforaphane 9μM R08 exp526 no dilution day6	1.9
Rapamycin 10μM R00 exp30	2
5-Fluorouracil 20μM R00 exp2	2.04
Lead acetate 2000μM R08 exp498 no dilution day6	2.07
BI-D1870 2μM R04 exp162	2.16
UM0131023 0.05μM R05 exp248	2.23
Latrunculin-B 10μM R07 exp374	2.24
Tubacin 1.6μM R07 exp416	2.37
LB-100 2μM R05 exp210	2.39
Betulinic acid 10 to 15μM on day4 R05 exp222	2.53
Cytochalasin-B 5μM R07 exp349	2.55
Lead acetate 2000μM R08 exp497	2.57
Arsenic trioxide 60μM R08 exp449	2.71
TRAIL 50ng/ml R00 exp36	2.73
CB-5083 0.4μM R08 exp468	2.75
Calcium Ionophore 0.4μM R07 exp342	2.79
Tozasertib 0.1μM R07 exp414	3.07
ML-792 0.2μM R08 exp505	3.13
Aminopterin 0.005μM R07 exp335	3.17
Bortezomib 0.005μM R00 exp6	3.26
Actinomycin-D 0.001μM R00 exp3	3.29
TRAIL 5ng/ml R00 exp35	3.34
Methotrexate 0.01μM R08 exp501	3.45
Staurosporine 0.02μM R08 exp524	3.49
I-BRD9 4μM R07 exp365	3.67
Oligomycin-A 2μM R00 exp25	3.68
AICAR 240μM R05 exp211	5.03
GSK626616 14μM R08 exp485	5.53
AICAR 240μM R03 exp116	6.11

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6695
Expression level (log2 read counts): 7.8

Expression Distribution

Gene	Correlation
AK2	0.421
CNBP	0.415
TFDP1	0.414
IKZF2	0.402

regulation of telomere maintenance
regulation of chromosome organization
regulation of DNA metabolic process
nuclear speck
regulation of organelle organization
RNA binding