ZBTB2

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK343 3μM R03 exp124	-2.95
Brefeldin A 0.02μM R00 exp8	-1.75
Nocodazole 0.1μM R03 exp94	-1.7
MK-1775 0.32μM R02 exp75	1.73
Thapsigargin 0.005μM R07 exp407	1.8
Tubacin 1.6μM R07 exp416	1.8
Bortezomib 0.05μM R00 exp7	1.93
Bafilomycin-A1 0.009μM R08 exp454	1.99
Dynasore 10μM R04 exp180	2
UM131593 0.2μM R03 exp106	2.25
UM0125461 0.74μM R02 exp84	2.48
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.77

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
negative regulation of transcription by RNA polymerase II
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression