ZCCHC3
Gene Information
- Official Symbol: ZCCHC3
- Official Name: zinc finger CCHC-type containing 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 85364
- UniProt: Q9NUD5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| detection of virus |
| positive regulation of RIG-I signaling pathway |
| cellular response to exogenous dsRNA |
| regulation of RIG-I signaling pathway |
| regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway |
| cellular response to dsRNA |
| response to exogenous dsRNA |
| response to dsRNA |
| regulation of defense response to virus |
| positive regulation of type I interferon production |
| double-stranded DNA binding |
| regulation of type I interferon production |
| defense response to virus |
| positive regulation of immune effector process |
| activation of innate immune response |
| response to virus |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| positive regulation of cytokine production |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| cellular response to organic cyclic compound |
| positive regulation of response to external stimulus |
| activation of immune response |
| cellular response to nitrogen compound |
| regulation of cytokine production |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| zinc ion binding |
| positive regulation of immune response |
| response to organic cyclic compound |
| defense response to other organism |
| positive regulation of intracellular signal transduction |
| response to nitrogen compound |
| immune effector process |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| RNA binding |
| regulation of response to stress |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cabazitaxel 0.001μM R05 exp223 | -1.89 |
| NFN1 0.4μM R03 exp99 | -1.81 |
| Arsenate 40μM R06 exp264 | -1.75 |
| Taxol 0.004μM R03 exp103 | -1.75 |
| UM0130462 0.025 to 0.035μM day4 R05 exp247 | -1.74 |
| HMS-I2 5μM R06 exp287 | -1.72 |
| Palbociclib 1μM R07 exp382 | 1.8 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6637
- Expression level (log2 read counts): 6.2
Expression Distribution
ZCCHC3 Expression in NALM6 Cells: 6.2
