ZNF273

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Curcumin 6.5μM R06 exp277	-1.79
39°C R06 exp303	-1.78
Ribavirin 10 to 15μM on day4 R04 exp160	-1.72
EPZ-5676 30μM R05 exp233	1.73
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.75
Epothilone-B 0.0015μM R05 exp231	1.76
Ethanol 0.01 R05 exp234	2.34

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-C2H2
KRAB

DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific