ZNF598

Entrez Summary: Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012].
UniProt Summary: E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). {ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:28065601, ECO:0000269|PubMed:28132843}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK-1775 0.32μM R02 exp75	-2.59
Cycloheximide 0.2μM R00 exp15	-1.95
5-Fluorouracil 2μM R00 exp1	-1.94
Bleomycin 5μM R08 exp459	-1.89
3-Bromopyruvate 7μM R04 exp175	-1.86
Staurosporine 0.02μM R08 exp524	-1.82
Nutlin-3A 1.6μM R06 exp294	-1.7
IU1-47 25μM R04 exp182	1.87
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.17
Nifuroxazide 1μM R01 exp51	2.25
MLN-4924 0.2μM R00 exp21	3.49

Expression Distribution

rescue of stalled ribosome
ribosome binding
protein monoubiquitination
translational elongation
ubiquitin protein ligase activity
regulation of translation
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular amide metabolic process
protein modification by small protein conjugation or removal
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression