AMBRA1
Gene Information
- Official Symbol: AMBRA1
- Official Name: autophagy and beclin 1 regulator 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 55626
- UniProt: Q9C0C7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| WD40 |
GO Terms
| mitophagy |
| response to mitochondrial depolarisation |
| negative regulation of cardiac muscle cell apoptotic process |
| selective autophagy |
| negative regulation of striated muscle cell apoptotic process |
| positive regulation of phosphatidylinositol 3-kinase activity |
| GTPase binding |
| positive regulation of lipid kinase activity |
| regulation of cardiac muscle cell apoptotic process |
| negative regulation of muscle cell apoptotic process |
| autophagy of mitochondrion |
| regulation of striated muscle cell apoptotic process |
| mitochondrion disassembly |
| positive regulation of phospholipid metabolic process |
| regulation of phosphatidylinositol 3-kinase activity |
| phagocytic vesicle |
| autophagosome assembly |
| regulation of lipid kinase activity |
| organelle disassembly |
| autophagosome organization |
| regulation of muscle cell apoptotic process |
| autophagosome |
| regulation of phospholipid metabolic process |
| axoneme |
| positive regulation of autophagy |
| vacuole organization |
| positive regulation of lipid metabolic process |
| negative regulation of neuron apoptotic process |
| cellular response to starvation |
| neural tube development |
| macroautophagy |
| mitochondrial outer membrane |
| response to starvation |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| cellular response to nutrient levels |
| autophagy |
| process utilizing autophagic mechanism |
| cellular response to extracellular stimulus |
| ubiquitin protein ligase binding |
| regulation of neuron death |
| regulation of autophagy |
| cellular response to external stimulus |
| positive regulation of cellular catabolic process |
| regulation of lipid metabolic process |
| cellular component disassembly |
| positive regulation of catabolic process |
| mitochondrion organization |
| response to nutrient levels |
| response to extracellular stimulus |
| positive regulation of kinase activity |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| positive regulation of transferase activity |
| negative regulation of cell population proliferation |
| perinuclear region of cytoplasm |
| organelle assembly |
| regulation of cellular catabolic process |
| tube development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of transferase activity |
| embryo development |
| negative regulation of cell death |
| regulation of catabolic process |
| positive regulation of phosphorylation |
| epithelium development |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| mitochondrion |
| positive regulation of catalytic activity |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| regulation of cell death |
| cellular response to stress |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 8/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 2/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1013
- Expression level (log2 read counts): 5.54
Expression Distribution
AMBRA1 Expression in NALM6 Cells: 5.54
