DHX33
Gene Information
- Official Symbol: DHX33
- Official Name: DEAH-box helicase 33
- Aliases and Previous Symbols: N/A
- Entrez ID: 56919
- UniProt: Q9H6R0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization. {ECO:0000269|PubMed:21930779}.
Pfam Domains GO Terms
Pfam Domains
| Helicase C |
| HA2 |
| OB NTP bind |
| DEAD |
GO Terms
| rDNA binding |
| positive regulation of NLRP3 inflammasome complex assembly |
| NLRP3 inflammasome complex |
| ribosomal large subunit binding |
| regulation of NLRP3 inflammasome complex assembly |
| 3-5 RNA helicase activity |
| positive regulation of transcription by RNA polymerase I |
| regulation of transcription by RNA polymerase I |
| activating transcription factor binding |
| double-stranded RNA binding |
| positive regulation of type I interferon production |
| regulation of type I interferon production |
| translational initiation |
| positive regulation of NF-kappaB transcription factor activity |
| mRNA binding |
| positive regulation of protein complex assembly |
| positive regulation of DNA-binding transcription factor activity |
| translation |
| peptide biosynthetic process |
| regulation of DNA-binding transcription factor activity |
| positive regulation of cytokine production |
| regulation of protein complex assembly |
| positive regulation of cellular component biogenesis |
| amide biosynthetic process |
| peptide metabolic process |
| positive regulation of MAPK cascade |
| regulation of cytokine production |
| regulation of MAPK cascade |
| cellular amide metabolic process |
| nucleolus |
| regulation of cellular component biogenesis |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| regulation of protein phosphorylation |
| ATP binding |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.458 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 696/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 27/28 |
| bone | 25/26 |
| breast | 27/33 |
| central nervous system | 54/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 15/16 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 71/75 |
| lymphocyte | 16/16 |
| ovary | 25/26 |
| pancreas | 24/24 |
| peripheral nervous system | 12/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 28/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 286
- Expression level (log2 read counts): 7.04
Expression Distribution
DHX33 Expression in NALM6 Cells: 7.04
