GTF3C5
Gene Information
- Official Symbol: GTF3C5
- Official Name: general transcription factor IIIC subunit 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 9328
- UniProt: Q9Y5Q8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Tau95 |
GO Terms
| RNA polymerase III type 1 promoter sequence-specific DNA binding |
| RNA polymerase III transcription regulator recruiting activity |
| RNA polymerase III type 2 promoter sequence-specific DNA binding |
| RNA polymerase III general transcription initiation factor activity |
| 5S class rRNA transcription by RNA polymerase III |
| transcription factor TFIIIC complex |
| tRNA transcription by RNA polymerase III |
| RNA polymerase III preinitiation complex assembly |
| tRNA transcription |
| transcription initiation from RNA polymerase III promoter |
| rRNA transcription |
| transcription preinitiation complex assembly |
| transcription by RNA polymerase III |
| skeletal muscle cell differentiation |
| ncRNA transcription |
| skeletal muscle tissue development |
| skeletal muscle organ development |
| protein-DNA complex assembly |
| DNA-templated transcription, initiation |
| protein-DNA complex subunit organization |
| striated muscle tissue development |
| muscle organ development |
| muscle tissue development |
| muscle structure development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| cellular protein-containing complex assembly |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| DNA binding |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| tissue development |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Trimetrexate 0.03μM R08 exp535 | -2.02 |
| MLN-4924 2μM R00 exp22 | 2.01 |
| 6-Thio-2-deoxyguanosine 2μM R06 exp259 | 2.37 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 19/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 1/25 |
| breast | 3/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 3/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1358
- Expression level (log2 read counts): 6.3
Expression Distribution
GTF3C5 Expression in NALM6 Cells: 6.3
