H2AFZ
Gene Information
- Official Symbol: H2AZ1
- Official Name: H2A.Z variant histone 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3015
- UniProt: P0C0S5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. {ECO:0000269|PubMed:15878876}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1371
- Expression level (log2 read counts): 8.98
H2AFZ Expression in NALM6 Cells: 8.98
