LAS1L
Gene Information
- Official Symbol: LAS1L
- Official Name: LAS1 like ribosome biogenesis factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 81887
- UniProt: Q9Y4W2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22872859}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 140
- Expression level (log2 read counts): 6.7
LAS1L Expression in NALM6 Cells: 6.7
