METTL14

Gene Information

Official Symbol: METTL14
Official Name: methyltransferase like 14
Aliases and Previous Symbols: N/A
Entrez ID: 57721
UniProt: Q9HCE5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: The METTL3-METTL14 heterodimer forms a N6- methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194). N6- methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q3UIK4, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-D1870 2μM R04 exp162	-2.57
Epigallocatechin gallate 20μM R05 exp230	-2.15
UM0130462 0.025 to 0.035μM day4 R05 exp247	-2.14
Campthothecin 0.001μM R06 exp270	-2.06
SGC0946 7μM R03 exp151	-1.92
BH1 1μM R04 exp169	-1.89
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.85
Cerivastatin 0.15μM R05 exp226	-1.82
Isoniazid 100μM R08 exp494	-1.81
TRAIL 5ng/ml R00 exp35	-1.73
Geldanamycin 0.01μM R05 exp235	-1.72
SNS-032 25μM R07 exp401	1.76
MK2206 4μM R08 exp504	1.77
Mubritinib 0.2μM R01 exp48	1.77
AICAR 240μM R03 exp116	1.81
Cytochalasin-B 5μM R07 exp349	1.93
Latrunculin-B 10μM R07 exp374	2.17
Bisphenol S 100μM R08 exp458	2.27
Citral 50μM R06 exp274	2.3
Milciclib 2μM R08 exp502	2.42
Rotenone 0.07μM R08 exp431	2.57

Gene	Correlation
METTL3	0.494
CBLL1	0.475
GEMIN8	0.467
CXorf56	0.457
PTAR1	0.441
DPH1	0.439
ITPK1	0.436
RPP21	0.429
RABGGTB	0.418
YTHDF2	0.409
GEMIN7	0.407
RBM26	0.403

Global Fraction of Cell Lines Where Essential: 397/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	21/28
blood	12/28
bone	18/26
breast	17/33
central nervous system	33/56
cervix	3/4
colorectal	10/17
esophagus	8/13
fibroblast	0/1
gastric	9/16
kidney	11/21
liver	11/20
lung	39/75
lymphocyte	6/16
ovary	14/26
pancreas	17/24
peripheral nervous system	9/16
plasma cell	8/15
prostate	0/1
skin	5/24
soft tissue	3/9
thyroid	2/2
upper aerodigestive	15/22
urinary tract	22/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 1989
Expression level (log2 read counts): 5.55

Expression Distribution