NOP58

Entrez Summary: N/A
UniProt Summary: Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. {ECO:0000250, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Monensin 0.3μM R08 exp507	-2.18
INK128 0.2μM R02 exp70	-2.08
Q15 1 to 2μM on day4 R04 exp164	-1.73
Calcipotriol 5μM R08 exp464	1.71
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.73
Dihydrosphingosine 8μM R08 exp476	1.79
B02 10μM R08 exp453	1.82
GW501516 25μM R06 exp285	1.84
BI-2536 0.0042μM R03 exp95	1.93
PNU96415E 10μM R03 exp145	1.98
Nicotine 3000μM R08 exp510	2.22
SB203580 25μM R03 exp149	2.46
ETC-159 50μM R08 exp480	2.71

Global Fraction of Cell Lines Where Essential: 720/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	28/28
bone	25/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	19/20
lung	72/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	13/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Expression Distribution