PKMYT1
Gene Information
- Official Symbol: PKMYT1
- Official Name: protein kinase, membrane associated tyrosine/threonine 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9088
- UniProt: Q99640
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
GO Terms
| kinase activity |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| negative regulation of phosphatase activity |
| negative regulation of dephosphorylation |
| G2/M transition of mitotic cell cycle |
| cell cycle G2/M phase transition |
| regulation of mitotic nuclear division |
| regulation of phosphatase activity |
| regulation of nuclear division |
| regulation of dephosphorylation |
| meiotic cell cycle |
| protein kinase activity |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| protein serine/threonine kinase activity |
| negative regulation of hydrolase activity |
| regulation of protein serine/threonine kinase activity |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| mitotic cell cycle process |
| Golgi membrane |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| regulation of cell cycle process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| nucleolus |
| regulation of kinase activity |
| endoplasmic reticulum membrane |
| protein phosphorylation |
| regulation of transferase activity |
| Golgi apparatus |
| cell cycle process |
| endoplasmic reticulum |
| negative regulation of molecular function |
| regulation of cell cycle |
| regulation of hydrolase activity |
| phosphorylation |
| regulation of organelle organization |
| cell cycle |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| ATP binding |
| regulation of phosphorylation |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 456/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 14/28 |
| blood | 18/28 |
| bone | 12/26 |
| breast | 21/33 |
| central nervous system | 36/56 |
| cervix | 1/4 |
| colorectal | 11/17 |
| esophagus | 9/13 |
| fibroblast | 1/1 |
| gastric | 13/16 |
| kidney | 15/21 |
| liver | 14/20 |
| lung | 39/75 |
| lymphocyte | 11/16 |
| ovary | 16/26 |
| pancreas | 20/24 |
| peripheral nervous system | 11/16 |
| plasma cell | 11/15 |
| prostate | 0/1 |
| skin | 12/24 |
| soft tissue | 6/9 |
| thyroid | 1/2 |
| upper aerodigestive | 14/22 |
| urinary tract | 19/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 1524
- Expression level (log2 read counts): 6.96
Expression Distribution
PKMYT1 Expression in NALM6 Cells: 6.96
