RREB1
Gene Information
- Official Symbol: RREB1
- Official Name: ras responsive element binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6239
- UniProt: Q92766
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of wound healing, spreading of epidermal cells |
| regulation of wound healing, spreading of epidermal cells |
| positive regulation of lamellipodium morphogenesis |
| positive regulation of mammary gland epithelial cell proliferation |
| regulation of lamellipodium morphogenesis |
| regulation of mammary gland epithelial cell proliferation |
| positive regulation of lamellipodium organization |
| positive regulation of morphogenesis of an epithelium |
| positive regulation of substrate adhesion-dependent cell spreading |
| regulation of lamellipodium organization |
| regulation of substrate adhesion-dependent cell spreading |
| positive regulation of wound healing |
| positive regulation of response to wounding |
| positive regulation of cell-substrate adhesion |
| fibrillar center |
| regulation of wound healing |
| positive regulation of epithelial cell migration |
| positive regulation of cell morphogenesis involved in differentiation |
| regulation of response to wounding |
| regulation of morphogenesis of an epithelium |
| positive regulation of epithelial cell proliferation |
| regulation of cell-substrate adhesion |
| regulation of epithelial cell migration |
| Ras protein signal transduction |
| nuclear body |
| regulation of cell morphogenesis involved in differentiation |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| small GTPase mediated signal transduction |
| regulation of epithelial cell proliferation |
| positive regulation of cell projection organization |
| nuclear speck |
| positive regulation of cell adhesion |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| transcription by RNA polymerase II |
| regulation of cell morphogenesis |
| positive regulation of cell migration |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| positive regulation of locomotion |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| DNA-binding transcription factor activity |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of cell development |
| positive regulation of cell differentiation |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of anatomical structure morphogenesis |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| intracellular signal transduction |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12987
- Expression level (log2 read counts): 6.64
Expression Distribution
RREB1 Expression in NALM6 Cells: 6.64
