SDE2
Gene Information
- Official Symbol: SDE2
- Official Name: SDE2 telomere maintenance homolog
- Aliases and Previous Symbols: N/A
- Entrez ID: 163859
- UniProt: Q6IQ49
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S- phase progression (PubMed:27906959). {ECO:0000269|PubMed:27906959}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2037
- Expression level (log2 read counts): 5.71
SDE2 Expression in NALM6 Cells: 5.71
