SEMA6B
Gene Information
- Official Symbol: SEMA6B
- Official Name: semaphorin 6B
- Aliases and Previous Symbols: N/A
- Entrez ID: 10501
- UniProt: Q9H3T3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in both peripheral and central nervous system development. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| PSI |
| Sema |
GO Terms
| semaphorin receptor binding |
| negative regulation of axon extension involved in axon guidance |
| chemorepellent activity |
| negative regulation of axon guidance |
| regulation of axon extension involved in axon guidance |
| semaphorin-plexin signaling pathway |
| negative regulation of axon extension |
| regulation of axon guidance |
| negative chemotaxis |
| neural crest cell migration |
| negative regulation of chemotaxis |
| negative regulation of axonogenesis |
| neural crest cell development |
| mesenchymal cell development |
| stem cell development |
| neural crest cell differentiation |
| regulation of axon extension |
| negative regulation of cell morphogenesis involved in differentiation |
| negative regulation of developmental growth |
| regulation of extent of cell growth |
| negative regulation of neuron projection development |
| mesenchymal cell differentiation |
| stem cell differentiation |
| ameboidal-type cell migration |
| negative regulation of cell projection organization |
| regulation of cell size |
| negative regulation of cell growth |
| regulation of axonogenesis |
| regulation of chemotaxis |
| mesenchyme development |
| negative regulation of neuron differentiation |
| negative regulation of growth |
| negative regulation of neurogenesis |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| negative regulation of locomotion |
| regulation of developmental growth |
| negative regulation of cell development |
| negative regulation of response to external stimulus |
| regulation of cellular component size |
| regulation of cell growth |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| positive regulation of cell migration |
| regulation of anatomical structure size |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| regulation of neuron differentiation |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| regulation of neurogenesis |
| regulation of cell migration |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| cell migration |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| negative regulation of multicellular organismal process |
| locomotion |
| integral component of plasma membrane |
| generation of neurons |
| movement of cell or subcellular component |
| extracellular space |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| tissue development |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| TCEB3CL | 0.471 |
| TCEB3CL2 | 0.463 |
| TCEB3C | 0.457 |
| PSMC1 | 0.455 |
| C1QTNF9B | 0.451 |
| IGFN1 | 0.443 |
| TBC1D3C | 0.436 |
| PSMB4 | 0.434 |
| RAD51 | 0.426 |
| ATP6V0C | 0.425 |
| GOLGA6L3 | 0.422 |
| SLC6A17 | 0.422 |
| TBC1D3G | 0.419 |
| HAP1 | 0.418 |
| TWISTNB | 0.417 |
| NUPL1 | 0.414 |
| TBC1D3H | 0.413 |
| CCDC64B | 0.412 |
| SUPT5H | 0.408 |
| GOLGA6L1 | 0.408 |
| SLC38A7 | 0.406 |
| SUPT6H | 0.405 |
| UPF1 | 0.403 |
| COPZ1 | 0.402 |
| CHAF1A | 0.4 |
| PRPF8 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2185
- Expression level (log2 read counts): 2.33
Expression Distribution
SEMA6B Expression in NALM6 Cells: 2.33
