SRRT
Gene Information
- Official Symbol: SRRT
- Official Name: serrate, RNA effector molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 51593
- UniProt: Q9BXP5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| DUF3546 |
| ARS2 |
GO Terms
| primary miRNA processing |
| neuronal stem cell population maintenance |
| production of miRNAs involved in gene silencing by miRNA |
| response to arsenic-containing substance |
| production of small RNA involved in gene silencing by RNA |
| dsRNA processing |
| gene silencing by miRNA |
| posttranscriptional gene silencing by RNA |
| posttranscriptional gene silencing |
| snRNA transcription by RNA polymerase II |
| snRNA transcription |
| gene silencing by RNA |
| ncRNA transcription |
| stem cell population maintenance |
| maintenance of cell number |
| gene silencing |
| regulation of gene expression, epigenetic |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| ncRNA processing |
| RNA splicing |
| positive regulation of neurogenesis |
| ncRNA metabolic process |
| mRNA processing |
| transcription by RNA polymerase II |
| posttranscriptional regulation of gene expression |
| positive regulation of nervous system development |
| positive regulation of cell development |
| cell population proliferation |
| protein-containing complex |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| mRNA metabolic process |
| regulation of neurogenesis |
| RNA processing |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| positive regulation of developmental process |
| RNA binding |
| DNA binding |
| generation of neurons |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 88/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 4/28 |
| blood | 7/28 |
| bone | 3/26 |
| breast | 3/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 2/17 |
| esophagus | 3/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 5/20 |
| lung | 6/75 |
| lymphocyte | 2/16 |
| ovary | 4/26 |
| pancreas | 1/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 2/15 |
| prostate | 1/1 |
| skin | 1/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 3/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 72
- Expression level (log2 read counts): 8.08
Expression Distribution
SRRT Expression in NALM6 Cells: 8.08
