TSR2

Entrez Summary: The protein encoded by this gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. [provided by RefSeq, Oct 2016].
UniProt Summary: May be involved in 20S pre-rRNA processing. {ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
HARS	0.647

Global Fraction of Cell Lines Where Essential: 693/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	26/26
bone	26/26
breast	30/30
central nervous system	49/49
cervix	4/4
colorectal	17/17
esophagus	11/11
fibroblast	1/1
gastric	14/14
kidney	18/18
liver	19/19
lung	72/72
lymphocyte	16/16
ovary	25/25
pancreas	22/22
peripheral nervous system	15/15
plasma cell	12/12
prostate	1/1
skin	20/20
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/28
uterus	5/5

Expression Distribution