UniProt Summary: Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7. {ECO:0000269|PubMed:24000165}.
Pfam DomainsGO Terms
Pfam Domains
UQ con
GO Terms
ubiquitin conjugating enzyme activity
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
ATP binding
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)