UQCRFS1

Official Symbol: UQCRFS1
Official Name: ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Aliases and Previous Symbols: N/A
Entrez ID: 7386
UniProt: P47985
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Cytochrome b-c1 complex subunit Rieske, mitochondrial: Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (PubMed:28673544). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity). {ECO:0000250|UniProtKB:P47985, ECO:0000269|PubMed:28673544}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ethanol 0.01 R05 exp234	1.7
UM0125461 0.74μM R02 exp84	1.77

Global Fraction of Cell Lines Where Essential: 110/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	7/28
bone	1/26
breast	7/33
central nervous system	1/56
cervix	1/4
colorectal	3/17
esophagus	3/13
fibroblast	0/1
gastric	3/16
kidney	2/21
liver	6/20
lung	19/75
lymphocyte	1/16
ovary	2/26
pancreas	3/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	6/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	4/29
uterus	1/5

Expression Distribution