ZC3H7A

Entrez Summary: N/A
UniProt Summary: May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CVT-10216 0.1μM R06 exp278	-2.08
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.76
Aphidicolin 0.4μM R08 exp440	1.73
Hydroxyurea 100μM R07 exp329	1.78
Docosahexaenoic-acid 50μM R07 exp356	1.87
Diepoxybutane 3μM R07 exp354	1.88
Nocodazole 0.2μM R02 exp64	1.88
Actinomycin-D 0.001μM R00 exp3	1.97
MK-1775 0.32μM R02 exp75	2.03
BI-6727 0.04μM R03 exp98	2.04
Resveratrol 16μM R03 exp147	2.18
3-Bromopyruvate 7μM R04 exp175	2.28
JQ1 0.8μM R08 exp435	2.49
BML-284 0.09μM R08 exp460	2.53
Olaparib 4μM R08 exp512	3.07
Aminopterin 0.005μM R07 exp335	4.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution