Table of Contents

Talazoparib 0.006μM R06 exp299

Mechanism of Action

Inhibits PARP1 and PARP2, blocks ssDNA break repair, selectively toxic to BRCA1/2 negative cancers

Technical Notes

Compound References

  • PubChem Name: Talazoparib
  • Synonyms: BMN-673; LT-673
  • CAS #: 1207456-01-6
  • PubChem CID: 135565082
  • IUPAC: (11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8-tetraen-4-one
  • INCHI Name: InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1
  • INCHI Key: HWGQMRYQVZSGDQ-HZPDHXFCSA-N
  • Molecular Weight: 380.4
  • Canonical SMILES: CN1C(=NC=N1)C2C(NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F
  • Isomeric SMILES: CN1C(=NC=N1)[C@@H]2[C@H](NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F
  • Molecular Formula: C19H14F2N6O

Compound Supplier

  • Supplier Name: Med Chem Express
  • Catalog #: HY-16106
  • Lot #: 8329

Compound Characterization

Characterization data not available.

Dose Response Curve

  • Platform ID: Talazoparib
  • Min: 3.9365; Max: 86.6319





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 0.0035
IC40 N/A
IC50 0.0099
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
5/16ScoresViewViewViewViewView