CASP2
Gene Information
- Official Symbol: CASP2
- Official Name: caspase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 835
- UniProt: P42575
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Peptidase C14 |
| CARD |
GO Terms
| cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| ectopic germ cell programmed cell death |
| luteolysis |
| programmed cell death involved in cell development |
| cysteine-type endopeptidase activity involved in apoptotic process |
| extrinsic apoptotic signaling pathway in absence of ligand |
| signal transduction in absence of ligand |
| ovulation cycle process |
| execution phase of apoptosis |
| positive regulation of neuron apoptotic process |
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| neural retina development |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| signal transduction involved in mitotic DNA damage checkpoint |
| signal transduction involved in mitotic DNA integrity checkpoint |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| mitotic G1/S transition checkpoint |
| mitotic G1 DNA damage checkpoint |
| G1 DNA damage checkpoint |
| ovulation cycle |
| intrinsic apoptotic signaling pathway in response to DNA damage |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in cell cycle checkpoint |
| cellular response to mechanical stimulus |
| DNA damage response, signal transduction by p53 class mediator |
| positive regulation of cell cycle arrest |
| female gonad development |
| cysteine-type endopeptidase activity |
| positive regulation of neuron death |
| development of primary female sexual characteristics |
| mitotic DNA damage checkpoint |
| extrinsic apoptotic signaling pathway |
| negative regulation of G1/S transition of mitotic cell cycle |
| signal transduction in response to DNA damage |
| mitotic DNA integrity checkpoint |
| negative regulation of cell cycle G1/S phase transition |
| regulation of cell cycle arrest |
| female sex differentiation |
| signal transduction by p53 class mediator |
| DNA damage checkpoint |
| retina development in camera-type eye |
| DNA integrity checkpoint |
| intrinsic apoptotic signaling pathway |
| regulation of G1/S transition of mitotic cell cycle |
| mitotic cell cycle checkpoint |
| protein processing |
| regulation of cell cycle G1/S phase transition |
| positive regulation of apoptotic signaling pathway |
| cell cycle checkpoint |
| regulation of neuron apoptotic process |
| gonad development |
| negative regulation of mitotic cell cycle phase transition |
| response to mechanical stimulus |
| development of primary sexual characteristics |
| protein maturation |
| negative regulation of cell cycle phase transition |
| protein domain specific binding |
| sex differentiation |
| rhythmic process |
| aging |
| apoptotic signaling pathway |
| positive regulation of cell cycle process |
| negative regulation of mitotic cell cycle |
| regulation of neuron death |
| camera-type eye development |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| negative regulation of cell cycle process |
| cellular response to external stimulus |
| enzyme binding |
| eye development |
| visual system development |
| sensory system development |
| positive regulation of cell cycle |
| regulation of apoptotic signaling pathway |
| regulation of mitotic cell cycle phase transition |
| reproductive structure development |
| reproductive system development |
| regulation of cell cycle phase transition |
| sensory organ development |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| developmental process involved in reproduction |
| mitotic cell cycle |
| positive regulation of cell death |
| brain development |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| head development |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| apoptotic process |
| central nervous system development |
| negative regulation of cell death |
| cell cycle process |
| programmed cell death |
| identical protein binding |
| cell death |
| response to abiotic stimulus |
| regulation of cell cycle |
| mitochondrion |
| proteolysis |
| cell cycle |
| reproductive process |
| reproduction |
| regulation of apoptotic process |
| regulation of programmed cell death |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of cell communication |
| positive regulation of signaling |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| CRADD | 0.757 |
| C2CD3 | 0.723 |
| PIBF1 | 0.71 |
| CCDC41 | 0.699 |
| KIAA0753 | 0.695 |
| OFD1 | 0.693 |
| ODF2 | 0.66 |
| PIDD | 0.655 |
| ANKRD26 | 0.652 |
| FOPNL | 0.636 |
| CEP76 | 0.618 |
| TUBD1 | 0.613 |
| NIN | 0.598 |
| CEP120 | 0.598 |
| C14orf80 | 0.598 |
| SCLT1 | 0.595 |
| C16orf59 | 0.595 |
| CEP128 | 0.588 |
| CEP78 | 0.581 |
| CEP44 | 0.521 |
| TUBE1 | 0.494 |
| HYLS1 | 0.481 |
| IPP | 0.471 |
| FGFR1OP | 0.433 |
| WBP11 | 0.415 |
| RTTN | 0.411 |
| CNTRL | 0.408 |
| KIAA0586 | 0.408 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17371
- Expression level (log2 read counts): 6.83
Expression Distribution
CASP2 Expression in NALM6 Cells: 6.83
